Synthesis and Evaluation of Antimalarial Activity of Oxygenated 3‐alkylpyridine Marine Alkaloid Analogues
Identifieur interne : 001503 ( Main/Exploration ); précédent : 001502; suivant : 001504Synthesis and Evaluation of Antimalarial Activity of Oxygenated 3‐alkylpyridine Marine Alkaloid Analogues
Auteurs : Flaviane F. Hilário [Brésil] ; Renata Cristina De Paula [Brésil] ; Mariana L. T. Silveira [Brésil] ; Gustavo H. R. Viana [Brésil] ; Rosemeire B. Alves [Brésil] ; Juliana R. C. S. Pereira [Brésil] ; Luciana Maria Silva [Brésil] ; Rossimiriam P. De Freitas [Brésil] ; Fernando De Pilla Varotti [Brésil]Source :
- Chemical Biology & Drug Design [ 1747-0277 ] ; 2011-09.
English descriptors
- Teeft :
- Alkaloid, Analogue, Antimalarial, Antimalarial activity, Antimalarial drug development, Antimicrob agents, Antiplasmodial activity, Belo horizonte, Benzyl chloride, Cdcl3, Chem, Chem biol drug, Column chromatography, Continuous culture, Cytotoxicity, Ethyl acetate, Falciparum, Falciparum clone, General procedure, Good yields, Hexane etoac, Marine alkaloids, Marine alkaloids analogues, Marine sponges, Methyl acrylate, Methylene, Methylene chloride, Methylene chloride meoh, Mmol, Oily product, Organic layer, Oxygenated, Oxygenated analogues, Oxygenated marine alkaloids analogues, Pilla varotti, Plasmodium falciparum, Pure compound, Pure compounds, Pyridine, Pyridine alkaloids, Pyridine nitrogen, Reaction mixture, Refluxing toluene, Room temperature, Selectivity index.
Abstract
A series of new oxygenated analogues of marine 3‐alkylpyridine alkaloids were prepared from 3‐pyridinepropanol in few steps and in good yields. The key step for the synthesis of these compounds was a Williamson etherification under phase‐transfer conditions. All new compounds were evaluated for their antiplasmodial activity and cytotoxicity. A significant reduction in parasitaemia was observed for some of the prepared compounds, and the majority of them exhibited a selectivity index (SI) ranging from 2.78 to 15.58, which suggests that these compounds may be a promising class of substances with antimalarial activity.
A series of new oxygenated analogues of marine 3‐alkylpyridine alkaloids were prepared from 3‐pyridinepropanol in few steps and in good yields. All new compounds were evaluated for their antiplasmodial activity and cytotoxicity. A significant reduction in parasitemia was observed for some of the prepared compounds and the majority of them exibited a selectivity index (SI) ranging from 2.78 to 15.58, which suggests that these compounds may be a promising class of substances with antimalarial activity.
Url:
DOI: 10.1111/j.1747-0285.2011.01154.x
Affiliations:
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The key step for the synthesis of these compounds was a Williamson etherification under phase‐transfer conditions. All new compounds were evaluated for their antiplasmodial activity and cytotoxicity. A significant reduction in parasitaemia was observed for some of the prepared compounds, and the majority of them exhibited a selectivity index (SI) ranging from 2.78 to 15.58, which suggests that these compounds may be a promising class of substances with antimalarial activity.</div><div type="abstract">A series of new oxygenated analogues of marine 3‐alkylpyridine alkaloids were prepared from 3‐pyridinepropanol in few steps and in good yields. All new compounds were evaluated for their antiplasmodial activity and cytotoxicity. A significant reduction in parasitemia was observed for some of the prepared compounds and the majority of them exibited a selectivity index (SI) ranging from 2.78 to 15.58, which suggests that these compounds may be a promising class of substances with antimalarial activity.</div></front></TEI><affiliations><list><country><li>Brésil</li></country></list><tree><country name="Brésil"><noRegion><name sortKey="Hilario, Flaviane F" sort="Hilario, Flaviane F" uniqKey="Hilario F" first="Flaviane F." last="Hilário">Flaviane F. Hilário</name></noRegion><name sortKey="Alves, Rosemeire B" sort="Alves, Rosemeire B" uniqKey="Alves R" first="Rosemeire B." last="Alves">Rosemeire B. Alves</name><name sortKey="De Freitas, Rossimiriam P" sort="De Freitas, Rossimiriam P" uniqKey="De Freitas R" first="Rossimiriam P." last="De Freitas">Rossimiriam P. De Freitas</name><name sortKey="De Freitas, Rossimiriam P" sort="De Freitas, Rossimiriam P" uniqKey="De Freitas R" first="Rossimiriam P." last="De Freitas">Rossimiriam P. De Freitas</name><name sortKey="De Paula, Renata Cristina" sort="De Paula, Renata Cristina" uniqKey="De Paula R" first="Renata Cristina" last="De Paula">Renata Cristina De Paula</name><name sortKey="De Pilla Varotti, Fernando" sort="De Pilla Varotti, Fernando" uniqKey="De Pilla Varotti F" first="Fernando" last="De Pilla Varotti">Fernando De Pilla Varotti</name><name sortKey="De Pilla Varotti, Fernando" sort="De Pilla Varotti, Fernando" uniqKey="De Pilla Varotti F" first="Fernando" last="De Pilla Varotti">Fernando De Pilla Varotti</name><name sortKey="Pereira, Juliana R C S" sort="Pereira, Juliana R C S" uniqKey="Pereira J" first="Juliana R. C. S." last="Pereira">Juliana R. C. S. Pereira</name><name sortKey="Pereira, Juliana R C S" sort="Pereira, Juliana R C S" uniqKey="Pereira J" first="Juliana R. C. S." last="Pereira">Juliana R. C. S. Pereira</name><name sortKey="Silva, Luciana Maria" sort="Silva, Luciana Maria" uniqKey="Silva L" first="Luciana Maria" last="Silva">Luciana Maria Silva</name><name sortKey="Silveira, Mariana L T" sort="Silveira, Mariana L T" uniqKey="Silveira M" first="Mariana L. T." last="Silveira">Mariana L. T. Silveira</name><name sortKey="Viana, Gustavo H R" sort="Viana, Gustavo H R" uniqKey="Viana G" first="Gustavo H. R." last="Viana">Gustavo H. R. Viana</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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